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Health is not merely the absence of disease or infirmity but a state of complete physical, mental, and social well-being. This concept is based on the definition of “health” established by the World Health Organization (WHO) in 1948.

Specifically, it includes the following aspects:

Physical health: A state in which there are no illnesses or disabilities, allowing for normal daily activities.

Mental health: The ability to cope with stress and maintain emotional stability.

Social health: Having good relationships and active participation in society.

BMI (Body Mass Index) is an indicator of the balance between weight and height, serving as a guideline for assessing health risks associated with obesity and underweight. This program emphasizes maintaining BMI within the standard range (18.5–24.9) to minimize the following health risks.

Risks of Underweight (BMI < 18.5)

• Weakened immune system: Increased susceptibility to infections.
• Malnutrition: Health issues due to deficiencies in vitamins and minerals.
• Osteoporosis: Decreased bone density, leading to a higher risk of fractures.

Risks of Obesity (BMI ≥ 25)

• Increased risk of lifestyle-related diseases: Higher likelihood of developing diabetes, hypertension, and dyslipidemia.
• Cardiovascular diseases: Elevated risk of heart attacks and strokes.
• Other health conditions: Higher susceptibility to joint disorders, sleep apnea, and certain cancers (such as colorectal and breast cancer).

Prevention of lifestyle-related diseases: Maintaining a normal BMI helps stabilize blood sugar levels and blood pressure.

Comfort in daily life: Reduces physical strain and minimizes fatigue.

Improved mental health: Maintaining an appropriate weight enhances self-confidence and reduces stress.

Exceeding the standard BMI range increases the risk of death from diseases such as heart disease and diabetes, with mortality rates rising by approximately 30% for every 5 kg of weight gain. Conversely, being underweight is associated with a higher risk of death, primarily due to diseases related to smoking.

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies - PubMed

Although other anthropometric measures (eg, waist circumference, waist-to-hip ratio) could well add extra information to...

pubmed.ncbi.nlm.nih.gov

Recent studies have revealed that a type of gut bacteria, Blautia wexlerae (hereafter referred to as Blautia bacteria), has the potential to suppress weight gain and contribute to the improvement of diabetes.

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota - PMC

The gut microbiome is an important determinant in various diseases. Here we perform a cross-sectional study of Japanese ...

pmc.ncbi.nlm.nih.gov

In this study, with the cooperation of medical institutions across Japan, gut microbiota data from approximately 10,000 individuals were collected. The results showed that healthy individuals had a higher abundance of Blautia bacteria, whereas those with obesity or diabetes had lower levels of this bacterium.

Blautia bacteria have been found to produce ornithine and acetylcholine, substances that help suppress fat accumulation and reduce inflammation. In animal experiments, administering Blautia bacteria to mice fed a high-fat diet resulted in suppressed weight gain and blood sugar increases. These findings suggest that Blautia bacteria may play a role in weight management and diabetes prevention.

However, Blautia bacteria are sensitive to oxygen, making it difficult to directly introduce them. Therefore, it is necessary to consume foods that help promote the growth of these bacteria in the gut. For example, fermented foods containing barley and koji are said to aid in the growth of Blautia bacteria. In other words, incorporating these foods into your daily diet can help improve the gut environment.

Impact on Gut Microbiota Balance Through Gut Environment Improvement

Autophagy is a cellular mechanism that breaks down and recycles unnecessary proteins and waste materials. It gained significant attention after Professor Yoshinori Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his research on this process. Autophagy promotes the health of the intestinal mucosa and helps maintain a balanced gut environment. In other words, an improved gut environment creates favorable conditions for the proliferation of Blautia bacteria.

Health and Weight Loss Program Utilizing Scientific Data Analysis with ChatGPT

This program provides evidence-based weight loss support tailored for middle-aged and older adults. It aims to extend healthy life expectancy and prevent lifestyle-related diseases through a personalized approach that leverages individual data.

Data Analysis and Support with ChatGPT

This program utilizes ChatGPT for data analysis and optimization of health management. By effectively leveraging AI, it provides more efficient and personalized weight loss support through the following key aspects:

1.Health Data Analysis
The program collects data on participants’ weight, BMI, dietary habits, and exercise routines. Through ChatGPT-driven analysis, it provides optimized recommendations for improvement.

2.Advice Reflecting the Latest Scientific Findings
The program provides real-time, evidence-based advice on topics such as the impact of gut microbiota and the effects of autophagy. This supports a healthy transformation of the body based on the latest scientific knowledge.

3.Diet Progress Management and Motivation Maintenance
The program visualizes each participant’s progress based on data and provides appropriate feedback, supporting long-term adherence to their weight loss journey.

4.Optimization of Diet and Exercise Plans
The program suggests personalized dietary plans incorporating barley and fermented foods, along with aerobic exercise routines tailored to individual lifestyles.