Achievements

Published Papers

  • Liver-specific DICER1 syndrome model mice develop cystic liver tumors with defective primary cilia.J Pathol. doi: 10.1002/path.6320. 2024
  • WAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7. Oncogene 40(21):3695-3706. 2021
  • Extracellular microvesicles that originated adipose tissue derived mesenchymal stem cells have the potential ability to improve rheumatoid arthritis on mice. Regenerative Therapy 9;15:305-311. 2020
  • An improved Red/ET recombineering system and mouse ES cells culture conditions for the generation of targeted mutant mice. Experimental Animals 3;66(2):125-136. 2017
  • Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity. Nature Communications 6;7:12977. 2016
  • Development of Novel Small Hairpin RNAs That do not Require Processing by Dicer or AGO2. Molecular Therapy 24(7):1278-1289. 2016
  • Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Oncogene 16;33(42):5028-5038. 2014
  • TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass. Diabetologia. 57(3):542-553. 2014
  • Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity. Journal of Experimental Medicine 21;208(12):2403-2416. 2011
  • Generation of transgenic mice on an NOD/SCID background using the conventional microinjection technique. Biology of Reproduction 84(4):682-688. 2011
  • Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metabolism. 2;13(3):294-307. 2011
  • Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature Medicine 13(3):332-339. 2007
  • Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. Journal of Biological Chemistry 8;281(36):26602-26614. 2006
  • 機能性インスリン産生細胞の作製 東京医科大学雑誌 78 (4):339-347. 2020
  • 実験動物におけるゲノム編集技術の変遷と応用 東京医科大学雑誌 78 (2):159-162. 2020
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